571 Miles from Moline, Illinois to Mt Vernon, Kentucky. US-150 Runs along I-74 for many miles in Illinois and co-locates with its parent, US-50, for a few miles around Vincennes, Indiana. Once south of Louisville the road turns into a fairly typical central Kentucky rural route. Gentle hills with enough turns to keep riders smiling. It co-locates with US-31E for a while and then turns back to itself at Bardstown. In many parts the road has been turned into a four lane divided highway. The great scenery doesn't change, but the roadway certainly isn't a challenge.